Other agencies & respected journals recognised the seriousness of nexium-plavix interaction and alerted the medical community. So when when FDA finally issued a warning, then there is no reason not to pay heed if you are still doing this combination.
Feb 2009: The Canadian Medical Association Journal:
http://www.prescriber.org.uk/2009/02/ppi-interaction-with-clopidogrel/
Mar 2009: JAMA press release:
http://jama.ama-assn.org/cgi/content/abstract/301/9/937
May 2009: European Medicines Agency (EMEA) press release:
http://www.ema.europa.eu/humandocs/PDFs/EPAR/Plavix/32895609en.pdf
Nov 2009: FDA warning in :
http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/DrugSafetyInformationforHeathcareProfessionals
The only safer alternative recommended is pantoprazole as it does not affect CYP4502C19 which is necessary to activate Plavix.
http://www.theheart.org/article/1003033.do
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